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大麦町犬先天性感音神经性耳聋与数量性状基因座相关。

Congenital sensorineural deafness in dalmatian dogs associated with quantitative trait loci.

作者信息

Kluth Susanne, Distl Ottmar

机构信息

Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.

出版信息

PLoS One. 2013 Dec 4;8(12):e80642. doi: 10.1371/journal.pone.0080642. eCollection 2013.

DOI:10.1371/journal.pone.0080642
PMID:24324618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3851758/
Abstract

A genome-wide association study (GWAS) was performed for 235 Dalmatian dogs using the canine Illumina high density bead chip to identify quantitative trait loci (QTL) associated with canine congenital sensorineural deafness (CCSD). Data analysis was performed for all Dalmatian dogs and in addition, separately for brown-eyed and blue-eyed dogs because of the significant influence of eye colour on CCSD in Dalmatian dogs. Mixed linear model analysis (MLM) revealed seven QTL with experiment-wide significant associations (-log10P>5.0) for CCSD in all Dalmatian dogs. Six QTL with experiment-wide significant associations for CCSD were found in brown-eyed Dalmatian dogs and in blue-eyed Dalmatian dogs, four experiment-wide significant QTL were detected. The experiment-wide CCSD-associated SNPs explained 82% of the phenotypic variance of CCSD. Five CCSD-loci on dog chromosomes (CFA) 6, 14, 27, 29 and 31 were in close vicinity of genes shown as causative for hearing loss in human and/or mouse.

摘要

使用犬类Illumina高密度珠芯片对235只大麦町犬进行了全基因组关联研究（GWAS），以鉴定与犬先天性感音神经性耳聋（CCSD）相关的数量性状位点（QTL）。对所有大麦町犬进行了数据分析，此外，由于眼睛颜色对大麦町犬CCSD有显著影响，因此还分别对棕色眼睛和蓝色眼睛的犬进行了分析。混合线性模型分析（MLM）显示，在所有大麦町犬中，有7个与CCSD具有全实验显著关联（-log10P>5.0）的QTL。在棕色眼睛的大麦町犬中发现了6个与CCSD具有全实验显著关联的QTL，在蓝色眼睛的大麦町犬中发现了4个全实验显著的QTL。全实验与CCSD相关的单核苷酸多态性（SNP）解释了CCSD表型变异的82%。犬染色体（CFA）6、14、27、29和31上的5个CCSD位点紧邻在人类和/或小鼠中显示为导致听力损失的基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/4d4946b9b78f/pone.0080642.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/4e2926cad931/pone.0080642.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/3c325e73c345/pone.0080642.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/7b40b58b5368/pone.0080642.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e3fc225d0c4c/pone.0080642.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e521cae40cb1/pone.0080642.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/9ff2420d4f35/pone.0080642.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/0b4b5599e119/pone.0080642.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e56276450f64/pone.0080642.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/672c648e46e5/pone.0080642.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/387657e0b98c/pone.0080642.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/03230daa467a/pone.0080642.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/89fa2346d619/pone.0080642.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/6095ecb428d1/pone.0080642.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/4d4946b9b78f/pone.0080642.g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/4e2926cad931/pone.0080642.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/3c325e73c345/pone.0080642.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/7b40b58b5368/pone.0080642.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e3fc225d0c4c/pone.0080642.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e521cae40cb1/pone.0080642.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/9ff2420d4f35/pone.0080642.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/0b4b5599e119/pone.0080642.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/e56276450f64/pone.0080642.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/672c648e46e5/pone.0080642.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/387657e0b98c/pone.0080642.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/03230daa467a/pone.0080642.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/89fa2346d619/pone.0080642.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/6095ecb428d1/pone.0080642.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/3851758/4d4946b9b78f/pone.0080642.g014.jpg

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