通过在线激光光声检测法研究人体中乙烯的药代动力学。

Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection.

作者信息

Berkelmans H W A, Moeskops B W M, Bominaar J, Scheepers P T J, Harren F J M

机构信息

Department of Molecular and Laser Physics, University of Nijmegen, The Netherlands.

出版信息

Toxicol Appl Pharmacol. 2003 Aug 1;190(3):206-13. doi: 10.1016/s0041-008x(03)00164-9.

DOI:10.1016/s0041-008x(03)00164-9

PMID:12902191

Abstract

The pharmacokinetics of ethylene are determined using laser-based photoacoustic detection and a closed chamber setup. Concentration-time data are analyzed using a two-compartment and a physiologically based pharmacokinetic (PBPK) model. Endogenous production was 92 +/- 13 pmol/h/kg for the two-compartment model and 75 +/- 10 pmol/h/kg for the PBPK model. These values agree with previous work at our department but are significantly lower than published values based on gas chromatography. The blood:air partition coefficient in the PBPK model was determined by curve fitting, because simulations based on published values did not agree well with data. Curve fitting gave a value of 0.092 +/- 0.029. The real-time nature and high sensitivity of photoacoustic detection make it a useful addition to gas chromatography in closed chamber studies.

摘要

使用基于激光的光声检测和密闭腔室装置来测定乙烯的药代动力学。使用二室模型和基于生理的药代动力学（PBPK）模型分析浓度-时间数据。二室模型的内源性生成量为92±13 pmol/h/kg，PBPK模型为75±10 pmol/h/kg。这些值与我们科室之前的研究结果一致，但显著低于基于气相色谱法公布的值。PBPK模型中的血-气分配系数通过曲线拟合确定，因为基于公布值的模拟结果与数据不太相符。曲线拟合得出的值为0.092±0.029。光声检测的实时性和高灵敏度使其成为密闭腔室研究中气相色谱法的有益补充。