Hisaoka M, Haratake J, Nakamura Y, Itoh Y
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Acta Pathol Jpn. 1992 Dec;42(12):870-5. doi: 10.1111/j.1440-1827.1992.tb01892.x.
The pancreata of 15 autopsy cases of sudden infant death syndrome (SIDS) and those of 14 age-matched controls were examined qualitatively and quantitatively to re-evaluate the relationship between pancreatic islet abnormalities and sudden death in infancy. Histopathologically, a diffuse or focal form of nesidioblastosis and septal islets were frequently observed in the pancreata of both groups. Endocrine cell dysplasia was found only in 2 infants who had died of SIDS. Quantitatively, there was little difference of islet cell composition between the SIDS cases and the controls. A relatively high proportion of islet cell area to total pancreatic tissue area was demonstrated in the SIDS group (8.46 +/- 4.90% in the pancreatic head; 8.66 +/- 4.23% in the pancreatic body to tail) in comparison with the controls (5.32 +/- 1.77%; 5.63 +/- 1.60%). Although nesidioblastosis and septal islets were considered to be within the limits of normal variation during pancreatic development, endocrine cell dysplasia and quantitatively unusual proliferation of the pancreatic endocrine tissue suggest the possibility that abnormalities in the endocrine pancreas may be causally related to sudden death in infancy.
对15例婴儿猝死综合征（SIDS）尸检病例以及14例年龄匹配的对照者的胰腺进行了定性和定量检查，以重新评估胰岛异常与婴儿猝死之间的关系。组织病理学上，两组胰腺中均经常观察到弥漫性或局灶性成神经细胞增生症和间隔胰岛。仅在2例死于SIDS的婴儿中发现内分泌细胞发育异常。定量分析显示，SIDS病例与对照者之间的胰岛细胞组成差异不大。与对照组（5.32±1.77%；5.63±1.60%）相比，SIDS组胰岛细胞面积占胰腺组织总面积的比例相对较高（胰头为8.46±4.90%；胰体至胰尾为8.66±4.23%）。尽管成神经细胞增生症和间隔胰岛被认为在胰腺发育的正常变异范围内，但内分泌细胞发育异常和胰腺内分泌组织的定量异常增生提示内分泌胰腺异常可能与婴儿猝死存在因果关系。
