Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.
作者信息
Sugiyama T, Kittaka A, Takayama H, Tomioka M, Ida Y, Kuroda R
机构信息
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
出版信息
Nucleic Acids Symp Ser. 2000(44):41-2. doi: 10.1093/nass/44.1.41.
PMID:12903258
Abstract
We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.
摘要
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