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Introduction of a benzoyl group onto 6-chloropurine riboside in aqueous solution and its application to the synthesis of nucleoside derivatives.

作者信息

Maruyama T, Kozai S, Takamatsu S, Izawa K

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

出版信息

Nucleic Acids Symp Ser. 2000(44):103-4. doi: 10.1093/nass/44.1.103.

DOI:10.1093/nass/44.1.103
PMID:12903289
Abstract

A benzoyl group was introduced onto the 3'-hydroxyl group of 6-chloropurine riboside by treatment with benzoic anhydride in the presence of a base in aqueous solution. The product (3b) was converted to 9-(2,3-Di-deoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (1, FddA) in 6 steps, including radical deoxygenation.

摘要

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