Izawa Kunisuke, Takamatsu Satoshi, Katayama Satoshi, Hirose Naoko, Kozai Shigetaka, Maruyama Tokumi
AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki-ku, Kawasaki, Japan.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):507-17. doi: 10.1081/NCN-120021951.
Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3'-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.
描述了两种通过嘌呤核糖苷或嘌呤3'-脱氧核糖苷合成洛德诺辛（1，FddA，9-(2,3-二脱氧-2-氟-β-D-苏式-戊呋喃糖基)腺嘌呤）的工业合成方法。考虑到反应产率、经济性、安全性和环境问题，比较了脱氧和氟化方法的几种新应用。
