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Synthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF.

作者信息

Hirota K, Hattori R, Sajiki H, Monguchi Y, Muraoka O, Tanabe G

机构信息

Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.

出版信息

Nucleic Acids Symp Ser. 2000(44):113-4. doi: 10.1093/nass/44.1.113.

Abstract

A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.

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