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通过对6-羟基进行特殊掩蔽合成2'-取代肌苷类似物。

Synthesis of 2'-substituted inosine analogs via unusual masking of the 6-hydroxyl group.

作者信息

Casu Fabio, Harston Rebecca K, Chiacchio Maria A, Gumina Giuseppe

机构信息

Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2012;31(3):224-35. doi: 10.1080/15257770.2011.650254.

DOI:10.1080/15257770.2011.650254
PMID:22356237
Abstract

2'-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide. Graphical Abstract:

摘要

2'-修饰的肌苷类似物已通过6-氯嘌呤核糖苷经6-二甲基氨基嘌呤或6-苄氧基嘌呤中间体合成。二甲基氨基嘌呤中间体是通过从二甲基甲酰胺进行异常容易的二甲胺转移而获得的。图形摘要：

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