Comaish J S, Felix R H, McGrath H
Arch Dermatol. 1976 Jan;112(1):70-2.
A patient with tuberculous meningitis developed a pellagra-like skin eruption after treatment with isoniazid. Administration of the drug was continued, and a topical preparation of niacinamide (nico-tinamide) was applied to one half of the face and the back of one hand. The areas treated responded rapidly, and subsequently all affected areas of the patient were treated, with almost complete resolution of the rash. At the same time, there was noticeable improvement in the patient's depression and apathy. We suggest that all of these changes could be due to percutaneous absorption of niacinamide.
一名结核性脑膜炎患者在接受异烟肼治疗后出现了糙皮病样皮疹。继续使用该药物，并将烟酰胺（烟酰胺）外用制剂涂于半侧面部和一只手背。治疗部位反应迅速，随后对患者所有受累部位进行了治疗，皮疹几乎完全消退。与此同时，患者的抑郁和冷漠症状有了明显改善。我们认为所有这些变化可能是由于烟酰胺经皮吸收所致。
