Hansen Eric C, Lee Daesung
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
J Am Chem Soc. 2003 Aug 13;125(32):9582-3. doi: 10.1021/ja036374k.
Macrocyclic 1,3-dienes of a variety of ring sizes are formed in good yield via enyne metathesis. Both endo- and exo-products are observed depending on the size of the macrocycle. In general, 10-membered rings and smaller give exo-products, while 12-membered rings and larger give endo-products. The endo/exo selectivity and the E/Z ratio of the diene products can be further controlled by the presence of ethylene in the reaction.
通过烯炔复分解反应可以高产率地生成各种环大小的大环1,3 - 二烯。根据大环的大小，会观察到内型和外型产物。一般来说，10元环及更小的环生成外型产物，而12元环及更大的环生成内型产物。反应中乙烯的存在可以进一步控制二烯产物的内型/外型选择性以及E/Z比。
