Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Org Lett. 2010 Jun 18;12(12):2822-5. doi: 10.1021/ol100914b.
An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.
本文提出了一种高效的合成骨架多样的杂环小分子可能立体异构体的方法。使用主转动惯量（PMI）形状分析量化了非对映立体氨基丙炔醇不同分子内环化引起的形状变化。
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