Wei Chunmei, Li Chao-Jun
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
J Am Chem Soc. 2003 Aug 13;125(32):9584-5. doi: 10.1021/ja0359299.
A highly efficient three-component-coupling of aldehyde, alkyne, and amine (A3 Coupling) catalyzed by gold via C-H activation was developed in water. The reaction is general, and nearly quantitative yields of the corresponding propargylamines were obtained in most cases. Both aromatic and aliphatic aldehydes and amines can be used for the reaction. No additional cocatalyst or activator is required. A mechanistic rationale for the reaction has been proposed.
在水中开发了一种由金通过C-H活化催化的醛、炔烃和胺的高效三组分偶联反应（A3偶联反应）。该反应具有通用性，在大多数情况下，相应的炔丙胺几乎能定量生成。芳香醛和脂肪醛以及胺均可用于该反应。无需额外的助催化剂或活化剂。已提出该反应的机理依据。
