Xu Hang, Wang Jun, Wang Peng, Niu Xiyu, Luo Yidan, Zhu Li, Yao Xiaoquan
Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China
Department of Chemistry, School of Pharmacy, Nanjing Medical University Nanjing 211166 PR China.
RSC Adv. 2018 Sep 24;8(57):32942-32947. doi: 10.1039/c8ra06613b. eCollection 2018 Sep 18.
The heterogeneous Cu/CN catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CHCl and amines (AHA) without additional base. Moreover, the catalyst also showed highly catalytic activity in the synthesis of C1-alkynylated tetrahydroisoquinolines (THIQs) an A reaction of alkynes, aldehydes and THIQ. The Cu/CN-catalyzed multicomponent reactions exhibited good functional group tolerance in most examples. Furthermore, the easily prepared Cu/CN catalyst could be recovered and reused conveniently over 5 times without losing catalytic activities.
研究发现，非均相Cu/CN催化剂可在无额外碱的条件下，通过炔烃、CHCl和胺的三组分偶联反应（AHA）高效合成炔丙胺。此外，该催化剂在炔烃、醛和四氢异喹啉（THIQ）的反应中合成C1-炔基化四氢异喹啉（THIQs）时也表现出高催化活性。在大多数实例中，Cu/CN催化的多组分反应表现出良好的官能团耐受性。此外，易于制备的Cu/CN催化剂可方便地回收和重复使用5次以上而不丧失催化活性。
