Nolan David, Christiansen Frank
Centre for Clinical Immunology and Biomedical Statistics, 2nd Floor, North Block, Royal Perth Hospital, Wellington St, Perth 6000, Western Australia.
Expert Opin Drug Saf. 2003 Jan;2(1):95-101. doi: 10.1517/14740338.2.1.95.
Highlights are presented from this annual workshop, which was devoted to the investigation of adverse effects associated with antiretroviral therapy for HIV infection. Topics covered included the lipodystrophy syndrome, which encompasses body composition changes (subcutaneous fat wasting, visceral fat accumulation) and metabolic abnormalities (insulin resistance and dyslipidaemia). The relevance of HIV protease inhibitor-induced metabolic abnormalities to cardiovascular disease is discussed. Research in the areas of hyperlactataemia, abacavir hypersensitivity, and bone mineral density in the context of HIV infection is also briefly reviewed.
本文介绍了该年度研讨会的要点，该研讨会致力于研究与抗逆转录病毒疗法治疗HIV感染相关的不良反应。涵盖的主题包括脂肪代谢障碍综合征，其包括身体成分变化（皮下脂肪消耗、内脏脂肪堆积）和代谢异常（胰岛素抵抗和血脂异常）。讨论了HIV蛋白酶抑制剂引起的代谢异常与心血管疾病的相关性。还简要回顾了HIV感染背景下高乳酸血症、阿巴卡韦超敏反应和骨矿物质密度方面的研究。
