Salas-Salvadó J, García-Lorda P
Human Nutrition Unit, Facultat de Medicina i Ciències de la Salut de Reus, Universitat Rovira i Virgili, Reus, Spain.
Clin Nutr. 2001 Oct;20(5):379-91. doi: 10.1054/clnu.2001.0429.
Abnormalities in energy, protein, lipid and glucose metabolism have been described in HIV patients since the beginning of the epidemic. With the new antiretroviral agents, nutritional status and survival have improved dramatically. However, since these therapies were introduced, there have been more descriptions of metabolic abnormalities, some of which were similar to and others of which were in conflict with those reported in previous years. This paper reviews the complexity of the metabolic abnormalities in HIV infections before and after the introduction of highly active antiretroviral therapy, and discusses such etiopathogenic mechanisms as secondary infections, antiretroviral drugs and persistent immune activation, which may be involved in these derangements.
自艾滋病流行之初，就已发现HIV患者存在能量、蛋白质、脂质及葡萄糖代谢异常。随着新型抗逆转录病毒药物的出现，营养状况及生存率显著改善。然而，自这些疗法应用以来，代谢异常的描述更多了，其中一些与前几年报道的相似，另一些则与之冲突。本文回顾了高效抗逆转录病毒治疗前后HIV感染中代谢异常的复杂性，并讨论了可能参与这些紊乱的继发感染、抗逆转录病毒药物及持续免疫激活等发病机制。
