Kimura G, Ogurusu K, Soda R, Tada S, Takahashi K, Kimura I
Second Department of Medicine, Okayama University Medical School.
Arerugi. 1992 Dec;41(12):1717-21.
T-cell-derived lymphokine, IFN-gamma, has potent effects on B-cell differentiation and leukotriene C4 production in leukocytes, and inhibits the effect of IL-4 on IgE production. To investigate the role of IFN-gamma in the pathogenesis of bronchial asthma, we examined IFN-gamma production by peripheral blood mononuclear cells cultured with Candida antigen and serum Candida specific IgG1 antibody from 20 asthmatics. The results were as follows: 1) IFN-gamma production in non-atopic severe asthmatics was significantly higher than in healthy subjects, atopic mild and moderate asthmatics, and atopic severe asthmatics (p < 0.05). 2) There was a significant correlation between IFN-gamma production induced by Candida antigen and serum Candida specific IgG1 antibody (r = 0.72, p < 0.01). These results suggest that IFN-gamma may play an important role in the pathogenesis of non-atopic severe bronchial asthma.
T细胞衍生的淋巴因子γ干扰素对B细胞分化以及白细胞中白三烯C4的产生具有强大作用，并抑制白细胞介素4对IgE产生的作用。为了研究γ干扰素在支气管哮喘发病机制中的作用，我们检测了20名哮喘患者外周血单核细胞与念珠菌抗原及血清念珠菌特异性IgG1抗体共同培养时γ干扰素的产生情况。结果如下：1）非特应性重度哮喘患者的γ干扰素产生量显著高于健康受试者、特应性轻度和中度哮喘患者以及特应性重度哮喘患者（p<0.05）。2）念珠菌抗原诱导的γ干扰素产生与血清念珠菌特异性IgG1抗体之间存在显著相关性（r = 0.72，p<0.01）。这些结果表明，γ干扰素可能在非特应性重度支气管哮喘的发病机制中起重要作用。
