乳腺癌患者的17-酮类固醇尿排泄量

Urinary excretion of 17-ketosteroids in patients suffering from mammary cancer.

Görlich M, Heise E

Arch Geschwulstforsch. 1975;45(5):457-63.

Abstract

The excretion of dehydroepiandrosterone is lower in patients suffering from mammary cancer than in healthy women. 2. There doesn't exist any relation between the 17-ketosteroid excretion and the age of postmenopausal women. 3. Patients with mammary tumors in stages III and IV are characterized by a lower excretion of dehydroepiandrosterone in percental parts than patients in stages I and II. 4. In patients with mammary tumors in stages III and IV and in patients with recurrences independently from the tumor stages we find higher extrem values for aetiocholanolone and smaller ones for dehydroepiandrosterone than in the other stages. 5. The quotient of percental parts of excreted aetiocholanolone to dehydroepiandrosterone shows significantly higher values for patients with recurrences than without them. 6. The quotient of aetiocholanolone to dehydroepiandrosterone is not a valid factor for a postoperative control of recurrences of the disease.

摘要

乳腺癌患者的脱氢表雄酮排泄量低于健康女性。2. 绝经后女性的17 - 酮类固醇排泄量与年龄之间不存在任何关联。3. Ⅲ期和Ⅳ期乳腺肿瘤患者的脱氢表雄酮排泄百分率低于Ⅰ期和Ⅱ期患者。4. Ⅲ期和Ⅳ期乳腺肿瘤患者以及复发患者（与肿瘤分期无关）的本胆烷醇酮极值高于其他阶段，而脱氢表雄酮极值低于其他阶段。5. 复发患者排泄的本胆烷醇酮与脱氢表雄酮的百分率商值显著高于未复发患者。6. 本胆烷醇酮与脱氢表雄酮的商值并非该疾病术后复发控制的有效因素。