Duggan P M, McCowan L M, Stewart A W
Department of Obstetrics and Gynaecology, National Women's Hospital, New Zealand.
Aust N Z J Obstet Gynaecol. 1992 Nov;32(4):335-8. doi: 10.1111/j.1479-828x.1992.tb02846.x.
Doppler studies of the uterine and umbilical arteries were performed in 24 acutely hypertensive pregnant women. Women were divided into 2 groups: Group 1 (diastolic blood pressure (DBP) > 110 mm Hg) received placebo (n = 6) or 10 mg oral nifedipine (n = 9); Group 2 (DBP > or = 110 mm Hg) received 10 mg oral nifedipine (n = 5) or 10 mg intravenous hydralazine (n = 4). Treatment allocations were random within groups and the investigator and patient were blind to the treatments. Baseline flow velocity waveforms (FVW) and posttreatment FVW's at 30, 60 and 120 minutes were recorded. There was no significant difference between baseline and posttreatment FVW indices within or between groups. Placebo was as effective as nifedipine in lowering blood pressure over 2 hours of study. There were no significant adverse effects of treatment.
对24名急性高血压孕妇进行了子宫和脐动脉的多普勒研究。将这些妇女分为两组：第1组（舒张压（DBP）>110mmHg）接受安慰剂（n = 6）或10mg口服硝苯地平（n = 9）；第2组（DBP≥110mmHg）接受10mg口服硝苯地平（n = 5）或10mg静脉注射肼屈嗪（n = 4）。组内治疗分配是随机的，研究者和患者对治疗均不知情。记录了基线血流速度波形（FVW）以及治疗后30、60和120分钟时的FVW。组内或组间基线和治疗后FVW指数无显著差异。在2小时的研究中，安慰剂在降低血压方面与硝苯地平效果相同。治疗无显著不良反应。
