Puzey M S, Ackovic K L, Lindow S W, Gonin R
Department of Obstetrics and Gynaecology, University of Cape Town.
S Afr Med J. 1991 Feb 16;79(4):192-4.
The effect of nifedipine 5 mg administered sublingually to pregnant hypertensive patients was examined in a randomised controlled double-blind study. The effect on maternal blood pressure and the fetal umbilical artery Doppler waveform was studied for 30 minutes before and 30 minutes after administration of the drug or placebo. This dose resulted in a significant drop in maternal blood pressure 30 minutes after administration and did not result in a significant change in the Doppler umbilical artery waveform (in fetuses with normal waveforms) when compared with a control group.
在一项随机对照双盲研究中，对舌下含服5毫克硝苯地平的妊娠高血压患者的疗效进行了检查。在给予药物或安慰剂之前30分钟和之后30分钟，研究了对母体血压和胎儿脐动脉多普勒波形的影响。与对照组相比，该剂量在给药后30分钟导致母体血压显著下降，并且（在波形正常的胎儿中）未导致多普勒脐动脉波形发生显著变化。
