Dahl Hans-Henrik M, Wake Melissa, Sarant Julia, Poulakis Zeffie, Siemering Kirby, Blamey Peter
Gene Identification and Expression, Murdoch Childrens' Research Institute, Royal Children's Hospital, Parkville, Vic., Australia.
Audiol Neurootol. 2003 Sep-Oct;8(5):263-8. doi: 10.1159/000071998.
This study addressed the question of whether a hearing loss caused by mutations in the connexin 26 gene had a significant effect on language and speech perception outcomes in children using cochlear implants or hearing aids. The families of children who had participated in two previous studies of language development were invited to participate in this genetic study. From the 52 children whose families agreed to participate, 15 children with connexin 26 mutations in both chromosomes were identified. After taking into account other factors which are known to affect language development and speech perception in children with impaired hearing, no significant differences were found between the 15 children where connexin 26 was known to be the cause of deafness and the other 37 children in the study.
本研究探讨了由连接蛋白26基因的突变所导致的听力损失，对于使用人工耳蜗或助听器的儿童的语言和言语感知结果是否有显著影响。曾参与两项先前语言发展研究的儿童家庭受邀参与这项基因研究。在同意参与的52名儿童家庭中，鉴定出15名两条染色体均存在连接蛋白26突变的儿童。在考虑了其他已知会影响听力受损儿童语言发展和言语感知的因素后，发现在已知连接蛋白26为致聋原因的15名儿童与研究中的其他37名儿童之间，未发现显著差异。
