Guo Xi-min, Wang Chang-yong
Tissue Engineering Research Center, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Feb;25(1):83-7.
This paper reviewed recent advances in pancreatic islet transplantation research, including islet isolation, purification, culture, cryopreservation and immunoisolation. Latest progresses in induction of pancreatic stem cell and embryonic stem cell to differentiate into insulin-producing islets were also introduced. On the basis of the present situation and future development of islet transplantation-based therapies for diabetes, the author thought that allogeous islet transplantation is a main choice for type I diabetes today and pancreatic stem cell transplantation for tomorrow.
本文综述了胰岛移植研究的最新进展，包括胰岛分离、纯化、培养、冷冻保存和免疫隔离。还介绍了诱导胰腺干细胞和胚胎干细胞分化为产生胰岛素的胰岛的最新进展。基于以胰岛移植为基础的糖尿病治疗方法的现状和未来发展，作者认为同种异体胰岛移植是当今I型糖尿病的主要选择，而胰腺干细胞移植则是未来的选择。
