Nanji Sulaiman A, Shapiro A M James
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Diabetes Obes Metab. 2006 Jan;8(1):15-25. doi: 10.1111/j.1463-1326.2005.00476.x.
With recent advances in methods of islet isolation and the introduction of more potent and less diabetogenic immunosuppressive therapies, islet transplantation has progressed from research to clinical reality. Presently, several international centres have demonstrated successful clinical outcomes with high rates of insulin independence after islet transplantation. Ongoing refinements in donor pancreas procurement and processing, developments in islet isolation and purification technology, and advances in novel immunological conditioning and induction therapies have led to the acceptance of islet transplantation as a safe and effective therapy for patients with type 1 diabetes. This review provides a historical perspective of islet transplantation, outlines the recent advances and current clinical outcomes, and addresses the present challenges and future directions in clinical islet transplantation.
随着胰岛分离方法的最新进展以及更有效且致糖尿病作用较小的免疫抑制疗法的引入,胰岛移植已从研究阶段发展到临床实际应用阶段。目前,多个国际中心已证明胰岛移植取得了成功的临床效果,胰岛移植后胰岛素非依赖率很高。供体胰腺获取和处理方面的不断改进、胰岛分离和纯化技术的发展以及新型免疫预处理和诱导疗法的进步,使得胰岛移植被认可为1型糖尿病患者的一种安全有效的治疗方法。本综述提供了胰岛移植的历史视角,概述了近期进展和当前临床结果,并探讨了临床胰岛移植目前面临的挑战和未来方向。