Xu Yan, Li Shun-wei, Huang Xi-zhen, Cong Bo
Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Dec;24(6):632-4.
To explore the relationship between sleep architecture changes and cognitive impairment in patients with obstructive sleep apnea syndrome (OSAS).
Thirty-six patients with OSAS and 18 controls were administered polysomnography and neuropsychological tests of visual regeneration, digital symbol, comprehensive memory and digital span.
Performances on the visual regeneration test and digital symbol test in patients with OSAS were impaired significantly compared with the control group (P < 0.01). Patients' performance on the visual regeneration test was significantly associated with slow wave sleep duration (r = 0.423, P < 0.05) and that on the digital symbol test was significantly associated with REM sleep duration (r = 0.378, P < 0.05).
Slow wave sleep and REM sleep derivation may play a role in the cognitive impairment in patients with OSAS.
探讨阻塞性睡眠呼吸暂停综合征（OSAS）患者睡眠结构变化与认知障碍之间的关系。
对36例OSAS患者和18例对照组进行多导睡眠图检查以及视觉再生、数字符号、综合记忆和数字广度的神经心理学测试。
与对照组相比，OSAS患者在视觉再生测试和数字符号测试中的表现显著受损（P < 0.01）。患者在视觉再生测试中的表现与慢波睡眠时间显著相关（r = 0.423，P < 0.05），在数字符号测试中的表现与快速眼动睡眠时间显著相关（r = 0.378，P < 0.05）。
慢波睡眠和快速眼动睡眠异常可能在OSAS患者的认知障碍中起作用。
