Mathieu A, Mazza S, Décary A, Massicotte-Marquez J, Petit D, Gosselin N, Malo J, Montplaisir J
Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 boul. Gouin Ouest, Montréal, Que., Canada H4J 1C5.
Sleep Med. 2008 Jan;9(2):112-20. doi: 10.1016/j.sleep.2007.03.014. Epub 2007 May 21.
Patients with obstructive sleep apnea syndrome (OSAS) present cognitive deficits similar to those observed with aging. The aim of the study was to assess the effects of age on cognitive functions in OSAS patients. It was hypothesized that older OSAS patients will exhibit significant cognitive dysfunction relative to younger OSAS patients and controls.
Younger and older OSAS patients were compared to younger and older control subjects (age cut-off set at 50 yrs). Participants underwent a polysomnographic (PSG) and neuropsychological evaluation. Variables were analyzed by two-way analyses of variance (ANOVAs) with two factors: Group (control and OSAS) and Age (younger and older). Additionally, we evaluated the contribution of attentional deficits to cognitive dysfunction for each subgroup of patients by using Spearman correlation coefficients.
No Group-by-Age interaction was found for any neuropsychological variables (p<0.05). However, main Group and Age effects were found. Correlations indicated that attentional deficits contributed importantly to a poorer cognitive performance in younger OSAS patients only (p<0.01).
Our results are in agreement with those of the literature for both OSAS-related and aging-related cognitive deficits but did not demonstrate that age interacts with the effects of the OSAS condition to make those cognitive deficits worse.
阻塞性睡眠呼吸暂停综合征（OSAS）患者存在与衰老相关的类似认知缺陷。本研究旨在评估年龄对OSAS患者认知功能的影响。研究假设为，相较于年轻的OSAS患者和对照组，年长的OSAS患者将表现出显著的认知功能障碍。
将年轻和年长的OSAS患者与年轻和年长的对照受试者（年龄界限设定为50岁）进行比较。参与者接受了多导睡眠图（PSG）和神经心理学评估。变量通过双因素方差分析（ANOVA）进行分析，因素包括：组（对照组和OSAS组）和年龄（年轻和年长）。此外，我们通过使用Spearman相关系数评估了每个患者亚组中注意力缺陷对认知功能障碍的影响。
未发现任何神经心理学变量存在组×年龄交互作用（p<0.05）。然而，发现了主要的组效应和年龄效应。相关性表明，注意力缺陷仅对年轻OSAS患者较差的认知表现有重要影响（p<0.01）。
我们的结果与文献中关于OSAS相关和衰老相关认知缺陷的结果一致，但未证明年龄与OSAS状况的影响相互作用会使这些认知缺陷更严重。
