Liu Jian-min, Zhao Hong-yan, Ning Guang, Zhang Lian-zhen, Xu Man-yin, Chen Jia-lun
Department of Endocrinology, Rui-jin Hospital, Shanghai Second Medical University, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):250-3.
To investigate the relative contribution of fat mass and lean mass on bone mineral density (BMD) in premenopausal healthy women.
The BMD at lumbar spine, proximal femur and total body, together with fat mass and lean mass was determined by dual-energy X-ray absorptiometry (DEXA), the body height, weight, waist, and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated in 282 premenopausal women.
Fat mass was a major determinant for BMI, BMI and lean mass were positively related with L2-4, proximal femur and total body BMD (P = 0.000 for all), and lean mass were the only independent factor contributing to L2-4 (standardized coefficient beta = 0.282, P = 0.000), proximal femur (beta = 0.336, P = 0.000) and total body BMD (beta = 0.361, P = 0.000) in stepwise regression analysis. The relationship between BMI and BMD was further improved after controlling fat mass, while decreased or even lost when controlling lean mass.
Lean mass was an important factor determining BMD in premenopausal women.
探讨绝经前健康女性脂肪量和瘦体重对骨密度（BMD）的相对贡献。
采用双能X线吸收法（DEXA）测定282名绝经前女性的腰椎、股骨近端和全身的骨密度，以及脂肪量和瘦体重，同时测量身高、体重、腰围和臀围，并计算体重指数（BMI）和腰臀比。
脂肪量是BMI的主要决定因素，BMI和瘦体重与L2-4、股骨近端和全身骨密度呈正相关（均P = 0.000），在逐步回归分析中，瘦体重是影响L2-4（标准化系数β = 0.282，P = 0.000）、股骨近端（β = 0.336，P = 0.000）和全身骨密度（β = 0.361，P = 0.000）的唯一独立因素。控制脂肪量后，BMI与骨密度的关系进一步改善，而控制瘦体重后，这种关系减弱甚至消失。
瘦体重是绝经前女性骨密度的重要决定因素。
