[降钙素受体基因多态性与上海女性骨密度的相关性]

[Association of calcitonin receptor gene polymorphism with bone mineral density in Shanghai women].

作者信息

Zhao Hong-yan, Liu Jian-min, Ning Guang, Zhang Lian-zhen, Jiang Ling, Dai Meng, Xu Man-yin, Chen Jia-lun

机构信息

Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):258-61.

PMID:12905735

Abstract

OBJECTIVE

To investigate the association of calcitonin receptor (CTR) gene polymorphism with bone mineral density (BMD) in premenopausal and postmenopausal women.

METHODS

CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 184 premenopausal women and 199 postmenopausal women in Shanghai area. BMD at lumbar spine (L2-4) and femoral neck (FN) were measured by dual-energy X-ray absorptiometry (DEXA).

RESULTS

The distribution of CTR genotypes in 383 Shanghai women were CC genotype 83.8%, TC genotype 14.6%, TT genotype 1.6%, respectively. BMD at FN of CC genotype was significantly higher than TC and TT genotypes (P < 0.01) in postmenopausal women. But there was no difference in BMD of different CTR genotypes in premenopausal women. Multiple regression analysis showed that CTR genotypes were associated with FN BMD in postmenopausal women (P < 0.05).

CONCLUSIONS

The polymorphism of CTR gene was associated with BMD in postmenopausal women.

摘要

目的

探讨降钙素受体（CTR）基因多态性与绝经前及绝经后女性骨密度（BMD）的关系。

方法

采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对上海地区184例绝经前女性和199例绝经后女性的CTR基因型进行检测。采用双能X线吸收法（DEXA）测量腰椎（L2-4）和股骨颈（FN）的骨密度。

结果

383例上海女性中CTR基因型分布分别为CC基因型83.8%，TC基因型14.6%，TT基因型1.6%。绝经后女性中，CC基因型股骨颈骨密度显著高于TC和TT基因型（P<0.01）。但绝经前女性不同CTR基因型的骨密度无差异。多元回归分析显示，绝经后女性CTR基因型与股骨颈骨密度相关（P<0.05）。