诱导痰检测在监测哮喘气道炎症中的临床价值
[Clinical value of induced sputum test in monitoring airway inflammation in asthma].
作者信息
Zhang H B, Lin Y G, Zhao X M
机构信息
Department of Respiratory Diseases, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct;23(5):432-4.
OBJECTIVE
To explore the clinical value of induced sputum test in monitoring airway inflammation in asthmatic patients.
METHODS
The induced sputum test was done in 12 normal subjects and 21 asthmatic subjects; The levels of interleukin-8 (IL-8), eosinophil cation protein (ECP), malondialdehyde (MDA) in plasma and induced sputum in all subjects were measured.
RESULTS
The levels of IL-8, ECP, MDA in plasma and induced sputum in unstable asthmatic patients were significantly higher than those in stable asthmatic (P < 0.01), in which the levels of IL-8, ECP, MDA in both plasma and induced sputum were significantly higher than those in normal subjects(P < 0.05); In all asthmatic patients, the levels of IL-8, ECP, MDA in induced sputum were significantly higher than those in plasma.
CONCLUSION
The levels of IL-8, ECP, MDA in induced sputum could be used for monitoring airway inflammation in asthmatic patients.
目的
探讨诱导痰检测在监测哮喘患者气道炎症中的临床价值。
方法
对12名正常受试者和21名哮喘受试者进行诱导痰检测；测定所有受试者血浆及诱导痰中白细胞介素-8（IL-8）、嗜酸性粒细胞阳离子蛋白（ECP）、丙二醛（MDA）水平。
结果
不稳定哮喘患者血浆及诱导痰中IL-8、ECP、MDA水平显著高于稳定期哮喘患者（P<0.01），其中不稳定哮喘患者血浆及诱导痰中IL-8、ECP、MDA水平均显著高于正常受试者（P<0.05）；所有哮喘患者诱导痰中IL-8、ECP、MDA水平均显著高于血浆。
结论
诱导痰中IL-8、ECP、MDA水平可用于监测哮喘患者气道炎症。
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