Kiran Ravi P, Delaney Conor P, Senagore Anthony J, O'Brien-Ermlich Bridget, Mascha Edward, Thornton Julie, Fazio Victor W
Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Am J Gastroenterol. 2003 Aug;98(8):1783-9. doi: 10.1111/j.1572-0241.2003.07592.x.
The Short Form 36 (SF-36) questionnaire is the most widely accepted measure of quality of life (QOL); however, it is cumbersome to use and requires complicated analysis. The Cleveland Global Quality of Life (CGQL) is a simpler tool, which has been validated in patients with ulcerative colitis undergoing restorative proctocolectomy. This study validates CGQL in patients with Crohn's disease and determines the correlation of QOL measurement systems with disease activity as measured by the Crohn's Disease Activity Index (CDAI).
All patients with Crohn's disease presenting to this department between September 2001 and February 2002 were prospectively entered into a database, including demographic data, disease manifestations, Vienna classification, age at diagnosis, and duration of Crohn's disease. SF-36, CGQL, and CDAI scores were entered concurrently. Cronbach's alpha was used to assess the internal consistency among the components of the CGQL score. Correlation among various QOL measures was assessed with Spearman's test. Relationships between QOL measures and various baseline factors were assessed by Wilcoxon rank sum test, Student's t test, Kruskal-Wallis test, and Pearson's test, depending on the type and distribution of data. Change from baseline in the CGQL was assessed with the Wilcoxon signed rank test.
One hundred seventy-eight (178) patients were entered into the database, and 169 completed QOL and CDAI data. There was a significant correlation between SF-36 and CGQL. CGQL and SF-36 correlated similarly with CDAI. Neither patient age, gender, or smoking history were associated with CGQL.
CGQL correlates with disease activity and is a simple measure of QOL in Crohn's disease.
简明健康状况调查量表（SF - 36）问卷是生活质量（QOL）最广泛接受的衡量标准；然而，其使用繁琐且需要复杂的分析。克利夫兰全球生活质量量表（CGQL）是一个更简单的工具，已在接受结直肠全切除回肠肛管吻合术的溃疡性结肠炎患者中得到验证。本研究验证CGQL在克罗恩病患者中的有效性，并确定生活质量测量系统与克罗恩病活动指数（CDAI）所测量的疾病活动之间的相关性。
2001年9月至2002年2月间到该科室就诊的所有克罗恩病患者均被前瞻性地录入数据库，包括人口统计学数据、疾病表现、维也纳分类、诊断年龄和克罗恩病病程。同时录入SF - 36、CGQL和CDAI评分。采用Cronbach's α评估CGQL评分各组成部分之间的内部一致性。用Spearman检验评估各种生活质量测量指标之间的相关性。根据数据的类型和分布，采用Wilcoxon秩和检验、Student's t检验、Kruskal - Wallis检验和Pearson检验评估生活质量测量指标与各种基线因素之间的关系。用Wilcoxon符号秩检验评估CGQL相对于基线的变化。
178例患者被录入数据库，169例完成了生活质量和CDAI数据。SF - 36与CGQL之间存在显著相关性。CGQL和SF - 36与CDAI的相关性相似。患者年龄、性别或吸烟史均与CGQL无关。
CGQL与疾病活动相关，是克罗恩病生活质量的一种简单测量方法。
