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Development. Longing for ligand: hedgehog, patched, and cell death.

作者信息

Guerrero Isabel, Ruiz i Altaba Ariel

机构信息

Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Universidad Autónoma de Madrid, Madrid E-28049, Spain.

出版信息

Science. 2003 Aug 8;301(5634):774-6. doi: 10.1126/science.1088625.

DOI:10.1126/science.1088625
PMID:12907783
Abstract
摘要

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1
Development. Longing for ligand: hedgehog, patched, and cell death.发育。对配体的渴望:刺猬蛋白、patched蛋白与细胞死亡。
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The hedgehog signaling network.刺猬信号通路网络。
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A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.patched的功能获得性突变体解析了对刺猬信号梯度的不同反应。
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Dependence receptors: what is the mechanism?依赖受体:其机制是什么?
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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.从果蝇到小鼠的刺猬信号通路/补丁信号通路的保守性:刺猬信号对小鼠补丁基因的诱导作用
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Hedgehog signaling: measuring ligand concentrations with receptor ratios.刺猬信号通路:利用受体比率测量配体浓度。
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Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog.Ptch2,第二个小鼠的patched基因,与音猬因子共同表达。
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Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning.Apontic 直接激活 Hedgehog 和 cyclin E,以实现正常的器官生长和形态发生。
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Evaluation of the 'Hedgehog' signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva.
眼睑及结膜鳞状细胞癌和基底细胞癌中“刺猬”信号通路的评估
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Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway. hedgehog 信号通路的激活可防止脂多糖诱导的肺微血管内皮细胞损伤。
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In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish.在缺乏 Sonic hedgehog 的情况下,p53 诱导斑马鱼的细胞凋亡,并抑制视网膜细胞的增殖、细胞周期退出和分化。
PLoS One. 2010 Oct 21;5(10):e13549. doi: 10.1371/journal.pone.0013549.
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Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection.肽两亲纳米纤维递送 Sonic Hedgehog 蛋白减少海绵体神经切断术后阴茎平滑肌细胞凋亡。
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Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.Ptch1在乳腺形态发生中局部发挥作用,在导管延长中全身发挥作用。
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Neural influences on sonic hedgehog and apoptosis in the rat penis.神经对大鼠阴茎中声波刺猬因子及细胞凋亡的影响。
Biol Reprod. 2008 May;78(5):947-56. doi: 10.1095/biolreprod.107.064766. Epub 2008 Feb 6.