Seidenbecher Thomas, Laxmi T Rao, Stork Oliver, Pape Hans-Christian
Institut für Physiologie, Otto-von-Guericke-Universität, Leipziger Strasse 44, Magdeburg D-39120, Germany.
Science. 2003 Aug 8;301(5634):846-50. doi: 10.1126/science.1085818.
The amygdalohippocampal circuit plays a pivotal role in Pavlovian fear memory. We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice. Patterns of activity were related to fear behavior evoked by conditioned and indifferent sensory stimuli and contexts. Rhythmically synchronized activity at theta frequencies increased between the LA and the CA1 after fear conditioning and became significant during confrontation with conditioned fear stimuli and expression of freezing behavior. Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval.
杏仁核-海马回路在巴甫洛夫式恐惧记忆中起关键作用。我们在自由活动的恐惧条件化小鼠中同时记录了外侧杏仁核（LA）和海马CA1区的电活动。活动模式与条件性和非条件性感觉刺激及情境所诱发的恐惧行为相关。恐惧条件化后，LA和CA1之间以θ频率有节奏地同步活动增加，在面对条件性恐惧刺激和出现僵住行为时变得显著。杏仁核-海马网络中θ活动的同步化代表了条件性恐惧的神经元关联，有助于在记忆检索过程中改善神经元间的通信。
