Narayanan Rajeevan T, Seidenbecher Thomas, Kluge Christian, Bergado Jorge, Stork Oliver, Pape Hans-Christian
Institut für Physiologie I, Westfälische Wilhelms-Universität Münster, Robert-Koch-Str 27a, Münster, Germany.
Eur J Neurosci. 2007 Mar;25(6):1823-31. doi: 10.1111/j.1460-9568.2007.05437.x. Epub 2007 Apr 4.
The amygdala and the hippocampus are critically involved in the formation and retention of fear memories. However, their precise contribution to, and their interplay during, fear memory formation are not fully understood. In the present study we investigated network activities in the amygdalo-hippocampal system of freely behaving mice at different stages of fear memory consolidation and retention. Our data show enhanced theta phase synchronization in this pathway during the retrieval of fear memory at long-term (24 h post-training), but not short-term (2 min, 30 min and 2 h post-training) stages, following both contextual and auditory cued conditioning. However, retrieval of remotely conditioned fear (30 days post-training) failed to induce an increase in synchronization despite there still being memory retention. Thus, our data indicate that the amygdalo-hippocampal interaction reflects a dynamic interaction of ensemble activities related to various stages of fear memory consolidation and/or retention, and support the notion that recent and remote memories are organized through different network principles.
杏仁核和海马体在恐惧记忆的形成和保留过程中起着至关重要的作用。然而，它们在恐惧记忆形成过程中的具体作用以及相互作用尚未完全明确。在本研究中，我们调查了自由活动小鼠在恐惧记忆巩固和保留的不同阶段，杏仁核 - 海马体系统中的网络活动。我们的数据显示，在长期（训练后24小时）而非短期（训练后2分钟、30分钟和2小时）阶段，无论是情境性还是听觉线索性条件反射后，恐惧记忆提取过程中该通路的θ相位同步增强。然而，尽管仍存在记忆保留，但远期条件性恐惧（训练后30天）的提取未能诱导同步性增加。因此，我们的数据表明，杏仁核 - 海马体的相互作用反映了与恐惧记忆巩固和/或保留的各个阶段相关的整体活动的动态相互作用，并支持近期记忆和远期记忆通过不同网络原则组织的观点。
