Choy Hak, Kim Dong W
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Semin Oncol. 2003 Aug;30(4 Suppl 9):3-10. doi: 10.1016/s0093-7754(03)00268-9.
The combination of chemotherapeutic drugs with radiation therapy has perhaps been one of the most promising strategies for current cancer radiotherapy practice, and has a strong biologic rationale. Concurrent chemoradiotherapy has been shown to improve survival and locoregional control of various cancers compared with radiotherapy alone. This article reviews the biologic rationale and principles fundamental to the use of chemoradiotherapy, and discusses mechanistic interactions between drugs and radiation, the knowledge of which is essential in developing optimal treatment strategies. Chemotherapeutic agents, particularly those shown to augment the radiation response of tumors, will be reviewed, and novel compounds and some of the exciting emerging strategies for chemoradiotherapy will be presented.
化疗药物与放射治疗相结合可能是当前癌症放射治疗实践中最有前景的策略之一，并且具有强大的生物学理论依据。与单纯放射治疗相比，同步放化疗已被证明可提高各种癌症的生存率和局部区域控制率。本文综述了放化疗应用的生物学理论依据和基本原理，并讨论了药物与辐射之间的机制相互作用，了解这些知识对于制定最佳治疗策略至关重要。将对化疗药物，特别是那些已证明能增强肿瘤放射反应的药物进行综述，并介绍新型化合物以及一些令人兴奋的放化疗新兴策略。
