Laboratory of Nano- and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, USA.
Curr Pharm Des. 2012;18(19):2830-7. doi: 10.2174/138161212800626229.
Chemoradiotherapy is an important treatment paradigm in oncology and is part of the curative treatment for many solid cancers, such as lung, pancreatic and cervical cancers. One of the main goals in oncology research is to develop approaches that can improve the efficacy of chemoradiotherapy while minimizing treatment toxicity. A new and exciting approach is to incorporate advances in nanomedicine into chemoradiotherapy. Nanoparticles possess unique properties, such as preferential accumulation in tumors and minimal uptake in normal tissues, that make them ideally suited for delivering chemotherapy in chemoradiotherapy. In this review, we plan to discuss the rationale and evidence for applying nanomedicine to chemoradiotherapy.
放化疗是肿瘤学中的一种重要治疗模式，也是许多实体瘤（如肺癌、胰腺癌和宫颈癌）治愈性治疗的一部分。肿瘤学研究的主要目标之一是开发能够提高放化疗疗效同时最小化治疗毒性的方法。一种新的令人兴奋的方法是将纳米医学的进展纳入放化疗中。纳米粒子具有独特的性质，如在肿瘤中优先积累和在正常组织中最小摄取，使其非常适合在放化疗中递送化疗药物。在这篇综述中，我们计划讨论将纳米医学应用于放化疗的原理和证据。
