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[妊娠合并HELLP综合征的原发性抗磷脂综合征]

[Primary antiphospholipid syndrome associated with HELLP syndrome in pregnancy].

作者信息

Veres Katalin, Papp Károly, Lakos Gabriella, Szomják Edit, Szegedi Gyula, Soltész Pál

机构信息

Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, III. sz. Belgyógyászati Klinika, Intenzív Osztály.

出版信息

Orv Hetil. 2003 Jul 6;144(27):1353-6.

PMID:12908149
Abstract

Authors report the case of a pregnant woman with antiphospholipid syndrome associated with HELLP syndrome. Pregnancy was terminated because of severe preeclampsia. However the patient's condition worsened. New symptoms of antiphospholipid syndrome developed (deep vein thrombosis, ischaemic optic lesion) and ARDS, therefore respiratory therapy was introduced. Plasmaphereses were performed concomitantly with high-dose intravenous immunoglobulin, glucocorticoid, cyclophosphamide and anticoagulant therapy. She responded to the therapy well, and eventually recovered completely. There are only a few case reports about pregnancies complicated with the association of antiphospholipid syndrome and HELLP syndrome. To authors' best knowledge, this is the first Hungarian report about this rare and curious association and it's successful treatment.

摘要

作者报告了一例患有抗磷脂综合征合并HELLP综合征的孕妇病例。因重度子痫前期终止妊娠。然而,患者病情恶化。出现了抗磷脂综合征的新症状(深静脉血栓形成、缺血性视神经病变)和急性呼吸窘迫综合征(ARDS),因此开始进行呼吸治疗。同时进行了血浆置换,并给予大剂量静脉注射免疫球蛋白、糖皮质激素、环磷酰胺和抗凝治疗。她对治疗反应良好,最终完全康复。关于抗磷脂综合征与HELLP综合征合并妊娠的病例报告很少。据作者所知,这是匈牙利关于这种罕见且特殊关联及其成功治疗的首例报告。

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1
[Primary antiphospholipid syndrome associated with HELLP syndrome in pregnancy].[妊娠合并HELLP综合征的原发性抗磷脂综合征]
Orv Hetil. 2003 Jul 6;144(27):1353-6.
2
Association of HELLP syndrome with primary antiphospholipid syndrome--a case report.HELLP综合征与原发性抗磷脂综合征的关联——一例报告
Clin Rheumatol. 2008 Jan;27(1):111-3. doi: 10.1007/s10067-007-0687-x. Epub 2007 Aug 8.
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Atypical onset of antiphospholipid syndrome in pregnancy: a case report.妊娠期抗磷脂综合征的非典型发病:一例报告
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The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women.抗磷脂综合征中的HELLP综合征:15名女性16例病例的回顾性研究
Ann Rheum Dis. 2005 Feb;64(2):273-8. doi: 10.1136/ard.2003.019000.
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[Catastrophic antiphospholipid syndrome during pregnancy].[妊娠期灾难性抗磷脂综合征]
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[Hepatic hemorrhagic infarction in eclampsia and HELLP Syndrome associated with the antiphospholipid syndrome].子痫及与抗磷脂综合征相关的HELLP综合征中的肝出血性梗死
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An association between refractory HELLP syndrome and antiphospholipid antibodies during pregnancy; a report of 2 cases.妊娠期间难治性HELLP综合征与抗磷脂抗体之间的关联;2例报告。
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[Efficacy of the combined treatment with immunoglobulins and plasmapheresis in a pregnant woman with Rh alloimmunization and antiphospholipid antibodies].[免疫球蛋白与血浆置换联合治疗Rh同种免疫和抗磷脂抗体阳性孕妇的疗效]
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Patient with antiphospholipid syndrome accompanied by pre-eclampsia who developed hellp syndrome and eclampsia after abortion.抗磷脂综合征患者伴子痫前期,流产后并发 HELLP 综合征及子痫。
Chin Med J (Engl). 2012 Nov;125(22):4142-4.
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Antiphospholipid syndrome during pregnancy: associated with early onset of HELLP syndrome and liver infarctions.妊娠期抗磷脂综合征:与HELLP综合征及肝梗死的早期发作相关。
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引用本文的文献

1
Association of HELLP syndrome with primary antiphospholipid syndrome--a case report.HELLP综合征与原发性抗磷脂综合征的关联——一例报告
Clin Rheumatol. 2008 Jan;27(1):111-3. doi: 10.1007/s10067-007-0687-x. Epub 2007 Aug 8.