Fu Kefu, Huang Weijie, Lin Yi, Zhang Donghui, Hanks Timothy W, Rao Apparao M, Sun Ya-Ping
Department of Chemistry, Center for Advanced Engineering Fibers and Films, Howard L. Hunter Chemistry Laboratory, Clemson University, Clemson, South Carolina, USA.
J Nanosci Nanotechnol. 2002 Oct;2(5):457-61. doi: 10.1166/153348802760393981.
Single-walled (SWNTs) and multiple-walled (MWNTs) carbon nanotubes were solubilized via the esterification of nanotube-bound carboxylic acids by oligomeric polyethylene glycol compounds. The water-soluble samples were used as starting materials in reactions with bovine serum albumin (BSA) protein in ambient aqueous solutions. The reaction conditions were designed for thermodynamically favorable transformation from ester to amide linkages, yielding SWNT-BSA and MWNT-BSA conjugates. The results show that the use of soluble starting nanotube materials in an indirect functionalization method represents a valuable approach to the biomodification of carbon nanotubes.
通过用低聚聚乙二醇化合物将与纳米管结合的羧酸进行酯化反应，使单壁（SWNTs）和多壁（MWNTs）碳纳米管溶解。将水溶性样品用作在环境水溶液中与牛血清白蛋白（BSA）蛋白质反应的起始原料。设计反应条件以实现从酯键到酰胺键的热力学有利转化，从而得到SWNT-BSA和MWNT-BSA共轭物。结果表明，在间接功能化方法中使用可溶性起始纳米管材料是碳纳米管生物改性的一种有价值的方法。
