Braggion C, Pradal U, Mastella G
Cystic Fibrosis Center, Ospedale Civile Maggiore, Verona, Italy.
Acta Paediatr. 1992 Dec;81(12):1002-6. doi: 10.1111/j.1651-2227.1992.tb12163.x.
Transcutaneous hemoglobin saturation by pulse oximetry was evaluated during sleep and for 2-3 h during the day in 31 patients with cystic fibrosis (median age 15.2 years; range 7.6-33.6 years) and severe airway obstruction. Pulse oximetry readings were analyzed as a cumulative percentage of time in which oxygen saturation was < 90% during both sleep and daytime. Each patient was also examined using clinical and radiological scores, spirometry and arterial blood-gas analysis. The agreement between arterial and transcutaneous saturation was evaluated in 29 patients. The difference between transcutaneous and arterial saturation was 2.4 +/- 2.0% and it increased as arterial saturation decreased. Clinical and radiological scores and spirometry parameters showed a poor correlation with both overnight and daytime desaturation. An arterial saturation < 94% may indicate a risk of consistent desaturation. This occurred for more than 50% of the time in 11 of 20 patients during sleep and in 5 of 20 patients during daytime hours.
在31例囊性纤维化患者（中位年龄15.2岁；范围7.6 - 33.6岁）且伴有严重气道阻塞的情况下，于睡眠期间及白天2 - 3小时内通过脉搏血氧饱和度仪评估经皮血红蛋白饱和度。脉搏血氧饱和度读数被分析为睡眠和白天期间血氧饱和度<90%的累计时间百分比。每位患者还接受了临床和放射学评分、肺功能测定及动脉血气分析检查。对29例患者评估了动脉饱和度与经皮饱和度之间的一致性。经皮饱和度与动脉饱和度之间的差异为2.4 +/- 2.0%，且随着动脉饱和度降低而增加。临床和放射学评分以及肺功能测定参数与夜间和白天的低氧饱和度均显示出较差的相关性。动脉饱和度<94%可能表明存在持续低氧饱和度的风险。在20例患者中，11例在睡眠期间以及5例在白天期间，超过50%的时间出现这种情况。
