Allen M B, Mellon A F, Simmonds E J, Page R L, Littlewood J M
Department of Respiratory Medicine, St James's University Hospital, Leeds.
Arch Dis Child. 1993 Aug;69(2):197-201. doi: 10.1136/adc.69.2.197.
Sleep related arterial oxygen desaturation has been described in clinically stable young adults with cystic fibrosis. The incidence and severity of nocturnal oxygen desaturation in children during infective exacerbations and the changes that occur with treatment were examined. Forty five children with proved cystic fibrosis, median age 8.9 years, admitted to the Regional Cystic Fibrosis Unit underwent clinical evaluation, spirometry, and measurement of peak flow and nocturnal oxygen saturation on admission and after 10 days' treatment. There was a significant improvement in all the above measurements, with the averaged overnight saturation changing from a mean (SD) 92.7 (2.7)% to 94.3 (2.0)%, mean (SE) difference 1.58 (0.37). The time spent with a saturation 4% or more below their clinic value showed a marked improvement from 122 (152) minutes on the first night to 21 (30.7) on the second, mean (SE) difference 101 (22.4). Eight young children could not perform pulmonary function tests, all desaturated on the admission night. Nocturnal hypoxaemia is a common finding in young cystic fibrosis patients during infective exacerbations but improves with treatment. Overnight oximetry is simple to perform, well tolerated, and identifies patients with marked nocturnal desaturation.
睡眠相关的动脉血氧饱和度下降已在临床状况稳定的囊性纤维化青年患者中有所描述。研究人员对儿童感染性加重期夜间血氧饱和度下降的发生率和严重程度以及治疗过程中发生的变化进行了检查。45名确诊为囊性纤维化的儿童，年龄中位数为8.9岁，入住地区囊性纤维化治疗中心，在入院时和治疗10天后接受了临床评估、肺功能测定、峰值流量测量和夜间血氧饱和度测量。上述所有测量结果均有显著改善，平均夜间饱和度从平均（标准差）92.7（2.7）%变为94.3（2.0）%，平均（标准误）差异为1.58（0.37）。血氧饱和度低于其门诊值4%或更多的时间显示出明显改善，从第一晚的122（152）分钟降至第二晚的21（30.7）分钟，平均（标准误）差异为101（22.4）。8名幼儿无法进行肺功能测试，入院当晚均出现血氧饱和度下降。夜间低氧血症在囊性纤维化患儿感染性加重期很常见，但治疗后会有所改善。夜间血氧饱和度监测操作简单，耐受性好，可识别出夜间血氧饱和度显著下降的患者。
