Ekblad H, Kero P, Vuolteenaho O, Arjamaa O, Korvenranta H, Shaffer S G
Department of Pediatrics, University of Turku, Finland.
Acta Paediatr. 1992 Dec;81(12):978-82. doi: 10.1111/j.1651-2227.1992.tb12158.x.
We assessed the relation of atrial natriuretic peptide (ANP) to renal function on postnatal day 2 and day 5 in preterm infants. Plasma ANP concentration was measured by radioimmunoassay in two groups of preterm infants: group 1, gestational age less than 30 weeks, n = 10; and group 2, gestational age 30-34 weeks, n = 11. The identity of the immunoreactivity as ANP-28 was confirmed by HPLC. Plasma ANP was significantly higher in group 1 than in group 2 on day 2 and day 5 (p < 0.01) and ANP concentration decreased by day 5 in both groups (group 1, p < 0.01; group 2, p < 0.02). The results showed no correlation between plasma ANP concentration and urinary sodium excretion or creatinine clearance, which may be due to a blunted renal response to ANP, but other factors may be involved also. We conclude that preterm infants are able to release large amounts of ANP, but a high plasma ANP concentration does not correlate directly with renal regulation of sodium and water balance.
我们评估了早产婴儿出生后第2天和第5天时心房利钠肽（ANP）与肾功能的关系。通过放射免疫分析法测定了两组早产婴儿的血浆ANP浓度：第1组，胎龄小于30周，n = 10；第2组，胎龄30 - 34周，n = 11。通过高效液相色谱法确认了免疫反应性为ANP - 28。第2天和第5天时，第1组的血浆ANP显著高于第2组（p < 0.01），且两组中第5天时ANP浓度均下降（第1组，p < 0.01；第2组，p < 0.02）。结果显示血浆ANP浓度与尿钠排泄或肌酐清除率之间无相关性，这可能是由于肾脏对ANP反应迟钝，但也可能涉及其他因素。我们得出结论，早产婴儿能够释放大量ANP，但血浆ANP高浓度与肾脏对钠和水平衡的调节并无直接关联。
