Fleming G F, McElnay J C, Hughes C M
School of Pharmacy, The Queen's University of Belfast, Belfast, Northern Ireland.
Subst Use Misuse. 2003 Jul;38(9):1217-26. doi: 10.1081/ja-120018480.
In the United Kingdom number of products containing codeine in combination with nonopioid analgesics are available from pharmacies for purchase without a prescription. These products may be abused and it has been reported that in order to avoid nonopioid toxicity, some users may attempt to separate the components of combination analgesics, by mixing the dosage form in water and passing it through a coffee filtration apparatus (coffee filters). The present research sought to test the ease of separation of products available in the United Kingdom. The results obtained indicated that separation was possible; however, the extent of separation was influenced by the volume of water used and the product chosen. Healthcare professionals must be aware that separation may be attempted by those wishing to abuse codeine; however, significant nonopioid toxicity could still arise in the abuser.
在英国，含有可待因与非阿片类镇痛药组合的多种产品在药店无需处方即可购买。这些产品可能会被滥用，并且据报道，为了避免非阿片类药物毒性，一些使用者可能会尝试将复方镇痛药的成分分离出来，方法是将剂型溶于水中，然后通过咖啡过滤装置（咖啡滤纸）。本研究旨在测试英国市场上现有产品的分离难易程度。所得结果表明分离是可行的；然而，分离程度受用水量和所选产品的影响。医疗保健专业人员必须意识到，那些希望滥用可待因的人可能会尝试分离；然而，滥用者仍可能出现严重的非阿片类药物毒性。
