Kalachnik John E, Hanzel Thomas E, Sevenich Robert, Harder Stuart R
University of South Carolina, School of Medicine, Department of Pediatrics, Center for Disability Resources, Columbia, South Carolina, USA.
J Autism Dev Disord. 2003 Jun;33(3):349-54. doi: 10.1023/a:1024466819989.
Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums. These side effects may be inadvertently confused with other behavioral or psychiatric conditions, especially if exacerbation of existing challenging behavior occurs. This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method. When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of intervals (95% confidence band = 1.6% to 4.6%) to 0.1% of intervals (95% confidence band = 0% to 0.1%). Indicators suggesting review by appropriate medical personnel for possible clonazepam behavioral side effects are provided.
与氯硝西泮相关的行为副作用可能包括激动、攻击行为、多动、易怒、破坏财物和发脾气。这些副作用可能会被无意中与其他行为或精神状况混淆，尤其是在现有具有挑战性的行为加剧时。本报告描述了一名智力障碍患者，该患者在服用每天2毫克（0.02毫克/千克/天）氯硝西泮以治疗攻击行为、自我伤害行为、破坏财物和尖叫时出现行为加剧，这些行为通过15分钟部分时段记录测量方法进行测量。当氯硝西泮减量并停药后，这些行为从间隔时间的3.1%（95%置信区间 = 1.6%至4.6%）显著降至间隔时间的0.1%（95%置信区间 = 0%至0.1%）。文中提供了一些指标，建议由适当的医务人员对可能的氯硝西泮行为副作用进行评估。
