Hammock R, Levine W R, Schroeder S R
University of Kansas, Lawrence, Kansas 66045, USA.
J Autism Dev Disord. 2001 Feb;31(1):109-13. doi: 10.1023/a:1005626100084.
Atypical antipsychotic medications for self-injurious behavior (SIB), aggression, and destruction among people with mental retardation and development disabilities are becoming increasingly accepted. Most studies are on risperidone and fewer have been conducted on clozapine. The present single-blind study reports marked reductions in SIB and aggression of two persons with profound mental retardation who were nonresponsive to all other behavioral and psychopharmacological interventions, including risperidone. The most effective dose was 200 mg/day. Side effects were mild and the drug was tolerated well.
非典型抗精神病药物用于治疗智力发育迟缓及发育障碍人群的自伤行为（SIB）、攻击行为和破坏行为正越来越被人们所接受。大多数研究针对利培酮，而针对氯氮平的研究较少。本单盲研究报告称，两名重度智力发育迟缓患者，对包括利培酮在内的所有其他行为和心理药物干预均无反应，但其自伤行为和攻击行为显著减少。最有效剂量为每日200毫克。副作用轻微，药物耐受性良好。
