Tanaka Toyohito
Department of Pharmacology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1, Hyakunincho, Shinjuku-ku, 169-0073 Tokyo, Japan.
Food Chem Toxicol. 2003 Oct;41(10):1429-32. doi: 10.1016/s0278-6915(03)00162-5.
Bis(2-ethylhexyl) phthalate (DEHP) was given in the diet to provide levels of 0 (C) or 0.03% (T) from 5 weeks of age of the F(0) generation to birth of the F(1) generation in mice. At 9 weeks of age, each female was paired with one male from the same or another treatment groups (cross-mating: C/C, T/C, C/T, T/T), for a period of 5 days. The males were removed from females after 5 days, and the females were allowed to carry their litters to term and deliver. There were no adverse effects of DEHP on either litter size, litter weight and sex ratio at birth. The average body weight of male offspring was significantly increased in all treatment groups at birth. There were no adverse effects of DEHP on female offspring weight at birth. The dose level of DEHP in the present study produced no adverse effects on secondary sex ratio, which meant sex ratio at birth, in mice.
