神经系统疾病患者脑脊液（CSF）和血液中的蛋白质S-100B、神经元特异性烯醇化酶（NSE）、髓鞘碱性蛋白（MBP）和胶质纤维酸性蛋白（GFAP）
Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients.
作者信息
Lamers K J B, Vos P, Verbeek M M, Rosmalen F, van Geel W J A, van Engelen B G M
机构信息
Laboratory of Pediatrics and Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands.
出版信息
Brain Res Bull. 2003 Aug 15;61(3):261-4. doi: 10.1016/s0361-9230(03)00089-3.
In this study, data about protein S-100B, neuron-specific enolase, myelin basic protein and glial fibrillary acidic protein in cerebrospinal fluid and blood of patients with an acute or chronic progressive neurological disorder with brain damage are reviewed. Especially in disorders with acute brain damage, determination of these proteins in CSF and blood can be helpful to establish structural and/or functional brain damage to determine severity and prognosis of the disease process and to monitor treatment effects.
在本研究中，对患有急性或慢性进行性神经系统疾病且伴有脑损伤患者的脑脊液和血液中的蛋白质S-100B、神经元特异性烯醇化酶、髓鞘碱性蛋白和胶质纤维酸性蛋白的数据进行了综述。特别是在急性脑损伤的疾病中，测定脑脊液和血液中的这些蛋白质有助于确定结构性和/或功能性脑损伤，以判断疾病进程的严重程度和预后，并监测治疗效果。
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