Iwabe Tomio, Harada Tasuku, Sakamoto Yasuko, Iba Yumiko, Horie Sayako, Mitsunari Masahiro, Terakawa Naoki
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Nishimachi, Yonago, Japan.
Fertil Steril. 2003 Aug;80(2):300-4. doi: 10.1016/s0015-0282(03)00609-5.
To determine whether serum interleukin (IL)-6 can be measured in patients with ovarian endometriomas and whether these measurements are useful in managing this disease.
A controlled clinical study and an in vitro study.
Department of Obstetrics and Gynecology, Tottori University, Japan.Twenty-two patients with ovarian endometriomas.
INTERVENTION(S): Laparoscopic cystectomy for ovarian endometriomas was performed. Gonadotropin-releasing hormone (GnRH) agonist was administered for 3 months in nine patients before laparoscopic surgery. Endometriotic stromal cells obtained from patients with endometriomas with or without GnRH agonist treatment were cultured.
MAIN OUTCOME MEASURES(S): IL-6 concentrations in serum or supernatant of the cell culture were measured using ELISA.
The serum concentration of IL-6 in patients with endometriomas was higher at the time of diagnosis than in those without endometriomas. Laparoscopic surgery significantly reduced serum levels of IL-6. Serum IL-6 concentrations also decreased after treatment with GnRH agonist. IL-6 production was attenuated in the endometriotic stromal cells obtained from patients with GnRH agonist treatment compared with patients without such treatment.
CONCLUSION(S): GnRH agonist treatment may decrease IL-6 production in endometriotic cells. Measurement of serum IL-6 concentrations may be of value in managing patients with endometriomas.
确定卵巢子宫内膜异位囊肿患者血清白细胞介素（IL）-6是否可检测，以及这些检测结果对该疾病的治疗是否有用。
一项对照临床研究和一项体外研究。
日本鸟取大学妇产科。22例卵巢子宫内膜异位囊肿患者。
对卵巢子宫内膜异位囊肿进行腹腔镜囊肿切除术。9例患者在腹腔镜手术前3个月给予促性腺激素释放激素（GnRH）激动剂。对接受或未接受GnRH激动剂治疗的子宫内膜异位囊肿患者获取的异位内膜间质细胞进行培养。
采用酶联免疫吸附测定法（ELISA）检测细胞培养上清液或血清中的IL-6浓度。
子宫内膜异位囊肿患者诊断时血清IL-6浓度高于无子宫内膜异位囊肿患者。腹腔镜手术显著降低了血清IL-6水平。GnRH激动剂治疗后血清IL-6浓度也降低。与未接受GnRH激动剂治疗的患者相比，接受GnRH激动剂治疗患者获取的异位内膜间质细胞中IL-6生成减弱。
GnRH激动剂治疗可能会降低异位内膜细胞中IL-6的生成。检测血清IL-6浓度可能对子宫内膜异位囊肿患者的治疗有价值。
