Gross Roxann Diez, Atwood Charles W, Grayhack Judith P, Shaiman Susan
Department of Audiology and Speech Pathology, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
J Appl Physiol (1985). 2003 Dec;95(6):2211-7. doi: 10.1152/japplphysiol.00316.2003. Epub 2003 Aug 8.
The experiment was a prospective, repeated-measures design intended to determine how the variation of lung volume affects specific measures of swallowing physiology. Swallows were recorded in 28 healthy subjects, who ranged in age from 21 to 40 yr (mean age of 29 yr), by using simultaneous videofluoroscopy, bipolar intramuscular electromyography, and respiratory inductance plethysmography. Each subject swallowed three standardized pudding-like consistency boluses at three randomized lung volumes: total lung capacity, functional residual capacity, and residual volume. The results showed that pharyngeal activity duration of deglutition for swallows produced at residual volume was significantly longer than those occurring at total lung capacity or at functional residual capacity. No significant differences were found for bolus transit time or intramuscular electromyography of the superior constrictor. The results of this experiment lend support to the hypothesis that the respiratory system may have a regulatory function related to swallowing and that positive subglottic air pressure may be important for swallowing integrity. Eventually, new treatment paradigms for oropharyngeal dysphagia that are based on respiratory physiology may be developed.
该实验采用前瞻性重复测量设计，旨在确定肺容量变化如何影响吞咽生理学的特定指标。通过同步视频荧光透视、双极肌内肌电图和呼吸感应体积描记法，对28名年龄在21至40岁（平均年龄29岁）的健康受试者的吞咽情况进行记录。每位受试者在三个随机设定的肺容量下吞咽三团标准化的布丁样黏稠度食团：肺总量、功能残气量和残气量。结果显示，在残气量时吞咽的咽部活动持续时间显著长于在肺总量或功能残气量时吞咽的情况。食团通过时间或咽上缩肌的肌电图未发现显著差异。该实验结果支持以下假设：呼吸系统可能具有与吞咽相关的调节功能，并且声门下正压可能对吞咽完整性很重要。最终，可能会开发基于呼吸生理学的口咽吞咽困难新治疗模式。
