Hamilton M S, Shepherd P, Porter J, Richards J D
University College and Middlesex School of Medicine, London, UK.
Leuk Lymphoma. 1992 Nov;8(4-5):409-13. doi: 10.3109/10428199209051022.
We report two cases of acute myelomonocytic leukaemia with abnormal eosinophils (M4Eo) in which the presenting feature was small bowel obstruction. We suggest there is a unique clinicopathological association between small intestine involvement with leukaemia and the M4Eo subtype. Central nervous system involvement by myeloblastoma occurred in one of the two cases which is a recognised feature of M4Eo and should necessitate prophylaxis with intrathecal therapy. Inversion of chromosome 16 which is a cytogenetic marker for M4Eo was demonstrable in one of the two cases.
我们报告了两例伴有异常嗜酸性粒细胞的急性粒单核细胞白血病（M4Eo），其首发症状为小肠梗阻。我们认为白血病累及小肠与M4Eo亚型之间存在独特的临床病理联系。两例中的一例发生了成髓细胞瘤累及中枢神经系统的情况，这是M4Eo的一个公认特征，因此应进行鞘内治疗预防。两例中的一例检测到16号染色体倒位，这是M4Eo的细胞遗传学标志。
