Yalaz Mehmet, Hilmioglu Suleyha, Metin Dilek, Akisu Mete, Nart Deniz, Cetin Hasan, Ozturk Cengiz, Isik Ecmel, Kultursay Nilgun
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
J Med Microbiol. 2003 Sep;52(Pt 9):835-837. doi: 10.1099/jmm.0.05140-0.
Species of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. strictum. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. strictum in the brain, liver and heart.
枝顶孢属（头孢霉属）的菌种是机会性微生物，在环境中广泛存在，是土壤中的腐生菌，极少情况下可对人类致病。免疫缺陷患者中曾有播散性感染的描述，但此前仅在一名新生儿中报道过。本文报告一例患有局限枝顶孢菌血症的早产儿。该患者孕27周出生，出生体重870克。她需要强化呼吸管理，并在出生后第11天发生败血症。血液和脑脊液培养显示局限枝顶孢菌阳性。患者对两性霉素B加氟康唑治疗无反应，于出生后第25天死亡。尸检显示大脑、肝脏和心脏有局限枝顶孢菌所致病灶。
