Wei Daoyan, Xiong Henry Q, Abbruzzese James L, Xie Keping
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Int J Gastrointest Cancer. 2003;33(1):43-60. doi: 10.1385/IJGC:33:1:43.
Pancreatic cancer is a lethal disease characterized by early metastasis, local invasion, and resistance to conventional therapies. To understand its etiology and eventually make prevention of it possible and effective, appropriate carcinogenesis models will certainly help us understand the effects of environmental and genetic elements on pancreatic carcinogenesis. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis and the availability of biologically and clinically relevant model systems. Many of the existing pancreatic cancer carcinogenesis and metastasis animal models are described in this review. The advantages and disadvantages of each model and their clinical implications are discussed, and special attention is focused on experimental therapeutic strategies targeting pancreatic cancer metastasis.
胰腺癌是一种致命疾病，其特征为早期转移、局部侵袭以及对传统疗法耐药。为了解其病因并最终实现有效预防，合适的致癌模型无疑将有助于我们了解环境和遗传因素对胰腺癌发生的影响。开发控制癌症转移的新治疗策略迫在眉睫。完成这项任务依赖于我们对胰腺癌转移的细胞和分子生物学的了解以及具备生物学和临床相关的模型系统。本文综述了许多现有的胰腺癌致癌和转移动物模型。讨论了每种模型的优缺点及其临床意义，并特别关注针对胰腺癌转移的实验性治疗策略。
