Zhan Han-xiang, Xu Jian-wei, Wu Dong, Zhang Tai-ping, Hu San-yuan
Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province, 250012, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Cancer Lett. 2015 Feb 28;357(2):429-37. doi: 10.1016/j.canlet.2014.12.004. Epub 2014 Dec 8.
Resistance to conventional therapy and early distant metastasis contribute to the unsatisfactory prognosis of patients with pancreatic cancer. The concept of cancer stem cells (CSCs) brings new insights into cancer biology and therapy. Many studies have confirmed the important role of these stem cells in carcinogenesis and the development of hematopoietic and solid cancers. Recent studies have shown that CSCs regulate aggressive behavior, recurrence, and drug resistance in pancreatic cancer. Here, we review recent advances in pancreatic cancer stem cells (PCSCs) research. Particular attention is paid to the regulation mechanisms of pancreatic cancer stem cell functions, such as stemness-related signaling pathways, microRNAs, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment, and the development of novel PCSCs targeted therapy. We seek to further understand PCSCs and explore potential therapeutic targets for pancreatic cancer.
对传统治疗的耐药性和早期远处转移导致胰腺癌患者预后不尽人意。癌症干细胞（CSCs）的概念为癌症生物学和治疗带来了新的见解。许多研究证实了这些干细胞在致癌过程以及血液系统癌症和实体癌发展中的重要作用。最近的研究表明，CSCs在胰腺癌中调节侵袭性、复发和耐药性。在此，我们综述了胰腺癌干细胞（PCSCs）研究的最新进展。特别关注胰腺癌干细胞功能的调控机制，如干性相关信号通路、微小RNA、上皮-间质转化（EMT）和肿瘤微环境，以及新型PCSCs靶向治疗的进展。我们旨在进一步了解PCSCs并探索胰腺癌的潜在治疗靶点。
