Bastard J P, Rabasa-Lhoret R, Maachi M, Ducluzeau P H, Andreelli F, Vidal H, Laville M
Service de Biochimie et Hormonologie, Hôpital Tenon AP-HP, Paris, France.
Diabetes Metab. 2003 Jun;29(3):285-8. doi: 10.1016/s1262-3636(07)70038-1.
The hyperinsulinemic euglycemic glucose clamp method is the gold standard for measuring insulin resistance. However it is complex, and simple indexes have been developed. Some of them are based on formulae that calculate the product or the addition of fasting plasma insulin and glucose values whereas others are based on their ratios. We calculated several simple indexes of insulin resistance and compared them to hyperinsulinemic euglycemic clamp data in 111 subjects with a wide range of insulin resistance. We showed that indexes using insulin and glucose ratios in their formulae are poorly correlated with clamp measurements and give false evaluations, particularly in glucose-intolerant and type 2 diabetic subjects. Thus, whatever the glucose profile of study subjects, we suggest the use of a simple index based on the product or the addition of fasting plasma insulin and glucose values instead of their ratios to obtain insulin resistance evaluations close to the hyperinsulinemic euglycemic clamp technique.
高胰岛素正常血糖钳夹法是测量胰岛素抵抗的金标准。然而，该方法较为复杂，因此人们开发了一些简单的指标。其中一些指标基于计算空腹血浆胰岛素和葡萄糖值的乘积或相加的公式，而其他指标则基于它们的比值。我们计算了几种简单的胰岛素抵抗指标，并将其与111名胰岛素抵抗范围广泛的受试者的高胰岛素正常血糖钳夹数据进行了比较。我们发现，公式中使用胰岛素与葡萄糖比值的指标与钳夹测量值的相关性较差，并会给出错误的评估结果，尤其是在糖耐量受损和2型糖尿病患者中。因此，无论研究对象的血糖情况如何，我们建议使用基于空腹血浆胰岛素和葡萄糖值的乘积或相加而非比值的简单指标，以获得接近高胰岛素正常血糖钳夹技术的胰岛素抵抗评估结果。
